Pharmacokinetic of simvastatin study in Malaysian subjects
نویسندگان
چکیده
The pharmacokinetic of simvastatin 40 mg tablet was assessed in 9 healthy Malaysian male subjects after a single oral dose in Pinang Hospital, Malaysian. Blood samples were collected at specified time intervals, plasma separated and analyzed for simvastatin using validated LC-MS-MS method at unversiti sains Malaysia. The pharmacokinetic parameters AUC0-24 Cmax, Tmax, t1/2, Ke, Cl and Vd were determined from plasma concentration-time profile for simvastatin. The results of this current method were consistent with other methods previously reported.
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